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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
Depression and distress predict time to cardiovascular disease in dementia caregivers
Brent T Mausbach1, Thomas L Patterson, Yaron G Rabinowitz
1Department of Psychiatry, University of California, San Diego, CA 92093-0680, USA. bmausbach@ucsd.edu
Insights
Depressive symptoms and distress from patient behaviors increase cardiovascular disease (CVD) risk in dementia caregivers. Managing caregiver mental health is crucial for preventing CVD in this population.
Area of Science:
- Gerontology
- Public Health
- Psychiatry
Background:
- Dementia family caregivers experience significant psychological distress.
- Patient problem behaviors can exacerbate caregiver distress.
- Cardiovascular disease (CVD) is a leading cause of mortality.
Purpose of the Study:
- To investigate the association between depressive symptoms and distress from patient problem behaviors and the time to developing a cardiovascular disease (CVD) diagnosis.
- To assess the impact on 643 dementia family caregivers.
Main Methods:
- Longitudinal, prospective study design over 18 months.
- Caregivers free from CVD at baseline were assessed for CVD onset at 6, 12, and 18-month follow-ups.
- Days to CVD onset was the primary outcome measure.
Main Results:
- 32 participants (5%) developed CVD during the study.
- Higher depressive symptoms (p = .040) predicted shorter time to CVD diagnosis.
- Increased distress from patient problem behaviors (p = .034) also predicted shorter time to CVD diagnosis, after adjusting for covariates.
Conclusions:
- Elevated depressive symptoms may heighten caregivers' risk for developing cardiovascular disease (CVD).
- Caregiver distress stemming from patient behaviors is linked to an increased risk of negative health outcomes, including CVD.
- Interventions targeting caregiver mental well-being may mitigate CVD risk.
Objective:
This study assessed the impact of depressive symptoms and distress from patient problem behaviors on time to developing a diagnosis of cardiovascular disease (CVD) in a sample of 643 dementia family caregivers.
Design:
A longitudinal, prospective design was used. Over an 18-month period, caregivers free from a CVD diagnosis at baseline were assessed at 6, 12, and 18-month follow-ups for the onset of CVD.
Main Outcome Measures:
Days to the onset of CVD was the primary outcome.
Results:
Over the length of the study, 32 participants (5%) reported a diagnosis of CVD. After adjusting for sociodemographic and health factors (e.g., high blood pressure, age, smoking history), greater depressive symptoms (p = .040) and distress from patient problem behaviors (p = .034) were significant predictors of time to CVD diagnosis.
Conclusion:
This study suggests that increased depressive symptoms and reaction to patient problem behaviors (i.e., distress) may increase caregivers' risk for experiencing negative health outcomes, specifically CVD.
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