Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transfusion-associated microchimerism.

G H Utter1, W F Reed, T-H Lee

  • 1Department of Surgery, UC, Davis Medical Center, Sacramento, CA 95817, USA. garth.utter@ucdmc.ucdavis.edu

Vox Sanguinis
|September 12, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimated US Trends in SARS-CoV-2 Spike Antibody Concentrations and Correlation to Risk of First-Time Infections Based on Blood Donations, 2022.

The Journal of infectious diseases·2025
Same author

Performance of the new biological small- and wide-angle X-ray scattering beamline 13A at the Taiwan Photon Source.

Journal of applied crystallography·2022
Same author

Da Vinci SP robotic approach to colorectal surgery: two specific indications and short-term results.

Techniques in coloproctology·2022
Same author

Robotic-assisted resection for beyond TME rectal cancer: a novel classification and analysis from a specialized center.

Updates in surgery·2020
Same author

Estimated dates of detectable infection (EDDIs) as an improvement upon Fiebig staging for HIV infection dating.

Epidemiology and infection·2020
Same author

Use of real-world registry data: a hernia mesh example.

Hernia : the journal of hernias and abdominal wall surgery·2019
Same journal

Red cell alloantibodies in 71,525 Malaysian blood donations: Predominance of anti-Mia reflects GP.Mur-associated antigenic diversity.

Vox sanguinis·2026
Same journal

Barriers and enablers to non-remunerated plasma donation: A meta-synthesis of the qualitative literature using the theoretical domains framework.

Vox sanguinis·2026
Same journal

Haemolytic disease of the foetus and newborn due to anti-M: A systematic review.

Vox sanguinis·2026
Same journal

In vitro evaluation of apheresis platelet and plasma products collected and stored in non-DEHP disposable sets.

Vox sanguinis·2026
Same journal

Survey of national and regional rare donor programmes regarding Immunoglobulin A deficiency.

Vox sanguinis·2026
Same journal

Fibrinogen recovery in cryoprecipitate prepared from thawed plasma stored for 5 days post-thaw.

Vox sanguinis·2026
See all related articles

Blood transfusion can cause microchimerism, the presence of donor cells in recipients. This transfusion-associated microchimerism (TA-MC) is common in trauma patients and can persist for years.

Area of Science:

  • Immunology
  • Hematology

Background:

  • Microchimerism involves the stable persistence of allogeneic cells.
  • Blood transfusion is a newly identified cause of microchimerism.
  • Transfusion-associated microchimerism (TA-MC) is distinct from fetal-maternal microchimerism.

Purpose of the Study:

  • To investigate the frequency and etiology of transfusion-associated microchimerism (TA-MC).
  • To understand the characteristics and potential implications of TA-MC.

Main Methods:

  • Utilized advances in polymerase chain reaction (PCR) technology.
  • Analyzed data from patients with severe traumatic injuries receiving blood products.

Main Results:

  • TA-MC is strongly evidenced in trauma patients receiving fresh blood products after massive hemorrhage.

Related Experiment Videos

  • Predisposing factors include pre-transfusion immunologic deficits matching donor HLA type.
  • TA-MC affects ~10% of transfused injured patients, persisting for years to decades.
  • It involves up to 5% of circulating leukocytes and multiple lineages, suggesting hematopoietic engraftment.

    • Conclusions:

    • TA-MC is a common, enduring, and pronounced phenomenon following blood transfusion in specific patient populations.
    • Further research into TA-MC may elucidate clinical consequences and fundamental hematologic/immunologic processes.