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Published on: June 17, 2020
Methamphetamine use in deceased kidney donors impairs one-yr graft function
David S Inouye1, Katherine Kickertz, Linda L Wong
1Department of Surgery, University of Hawaii School of Medicine, Hawaii, USA.
Clinical Transplantation
|September 12, 2007
Summary
Methamphetamine (MA) exposure in kidney donors may impact recipient graft function. While initial creatinine levels were similar, one-year creatinine was higher in recipients of MA-exposed kidneys, though not independently significant.
Area of Science:
- Nephrology
- Transplantation
- Toxicology
Background:
- Methamphetamine (MA) has known detrimental effects on organ systems.
- Assessing the impact of MA exposure in deceased kidney donors on transplant recipients is crucial.
Purpose of the Study:
- To investigate the association between methamphetamine exposure in kidney donors and post-transplant graft function in recipients.
- To compare graft function outcomes between recipients of MA-exposed donor kidneys and controls.
Main Methods:
- Retrospective analysis of 97 deceased kidney donors from 2000-2004.
- Selection of 20 donors with documented MA exposure (history or toxicology).
- Comparison of one-year post-transplant serum creatinine (Cr365), delayed graft function, and rejection episodes between MA-exposed and control groups.
Main Results:
- Serum creatinine at seven days post-transplant was comparable between groups.
- One-year serum creatinine (Cr365) was significantly elevated in recipients of MA-exposed kidneys (p=0.028).
- MA exposure was not an independent predictor of increased Cr365 after adjusting for confounding variables (p=0.07-0.09).
Conclusions:
- Donor MA exposure may be associated with elevated one-year serum creatinine in kidney transplant recipients.
- Transplant centers should anticipate encountering donors with MA use histories.
- Larger studies are needed to confirm MA exposure as an independent predictor of impaired graft function.
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