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Updated: Jun 23, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Atherosclerosis secondary prevention performance measures after coronary bypass graft surgery compared with
Loren F Hiratzka1, Kim A Eagle, Li Liang
1Cardiac Vascular and Thoracic Surgeons, Inc., Cincinnati, Ohio, USA. loren_hiratzka@trihealth.com
Insights
Compliance with secondary prevention measures differs for coronary artery bypass graft (CABG) patients compared to nonsurgical patients. Process improvements are needed to enhance care for CABG patients receiving guideline-directed medical therapy.
Area of Science:
- Cardiology
- Healthcare Quality Improvement
- Public Health
Background:
- The American Heart Association Get With the Guidelines-Coronary Artery Disease program aims to improve atherosclerosis risk reduction strategies.
- Coronary artery bypass graft (CABG) surgery patients may experience different care pathways impacting compliance with secondary prevention measures.
Purpose of the Study:
- To compare compliance with secondary prevention performance measures between CABG patients and nonsurgical patients within the Get With the Guidelines-Coronary Artery Disease program.
Main Methods:
- A total of 119,106 patients were analyzed: 14,118 with CABG, 58,702 with percutaneous catheter intervention, and 46,286 with neither intervention.
- Compliance with medications (aspirin, beta-blockers, ACE inhibitors, lipid-lowering drugs) and smoking cessation counseling was assessed.
- Statistical adjustments were made for 14 clinical variables to compare outcomes.
Main Results:
- CABG patients were less likely to receive most secondary prevention measures compared to percutaneous catheter intervention patients.
- However, CABG patients were more likely to receive aspirin, beta-blockers, and smoking cessation counseling than patients receiving neither intervention.
- Composite adherence and defect-free rates were highest for percutaneous catheter intervention patients and lowest for patients receiving neither intervention after adjustment.
Conclusions:
- Significant disparities exist in hospital discharge compliance with secondary prevention measures for CABG versus nonsurgical patients.
- Differences in care processes likely contribute to these compliance variations and warrant further investigation.
- Targeted quality improvement interventions for CABG patients are crucial, given the proven benefits of secondary prevention in this population.
Background:
The American Heart Association Get With the Guidelines-Coronary Artery Disease program facilitates patient and physician compliance with proven atherosclerosis risk reduction strategies with collaborative learning sessions, teaching materials, predischarge online check lists, and web-based performance measure feedback for continuous quality improvement. Patients having coronary artery bypass graft surgery (CABG) may be subject to different care processes, nursing unit pathways, and personnel than patients having percutaneous catheter intervention or neither intervention, which may affect compliance.
Methods And Results:
The Get With the Guidelines-Coronary Artery Disease database was queried to determine whether compliance with secondary prevention performance measures for CABG patients was different from that for nonsurgical patients. A total of 119,106 patients were treated with CABG (14,118), percutaneous catheter intervention (58,702), or neither intervention (46,286). Compliance with medication prescriptions, including aspirin, beta-blockers, angiotensin-converting enzyme inhibitors, and lipid-lowering drugs, and smoking cessation counseling for eligible patients was analyzed. Medically appropriate exclusions and contraindications were included in the analysis. After adjusting for 14 clinical variables, CABG patients were less likely to receive most secondary prevention measures relative to percutaneous catheter intervention patients. In contrast, CABG patients were more likely to receive aspirin, beta-blocker, and smoking cessation counseling than neither intervention patients. Composite adherence and defect-free rates were highest for percutaneous catheter intervention patients and lowest for neither intervention patients after adjustment.
Conclusions:
There are significant differences in compliance at hospital discharge with secondary prevention performance measures for CABG patients compared with nonsurgical patients. Process of care differences may explain these differences and should be examined further because significant opportunities for improved compliance are evident. CABG patients in particular represent a group for whom secondary prevention has proven benefits, and they may benefit from future quality improvement interventions.
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