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[Right ventricular function in sleep apnea syndrome and chronic obstructive pulmonary disease]
A Valera Sánchez1, A Ramos Ruiz, E Rodríguez Becerra
1Servicio de Neulología, Hospital Universitario Virgen del Rocío, Sevilla.
Revista Clinica Espanola
|November 1, 1991
Summary
Daytime hypoxemia, not COPD, significantly worsens right ventricular function in sleep apnea syndrome patients. This finding highlights hypoxemia as a key factor in developing chronic cor pulmonale.
Area of Science:
- Cardiology
- Pulmonology
- Sleep Medicine
Background:
- Chronic cor pulmonale (CCP) development in sleep apnea syndrome (SAS) is multifactorial.
- The impact of coexisting chronic obstructive pulmonary disease (COPD) on CCP in SAS requires further investigation.
Purpose of the Study:
- To evaluate right ventricular (RV) function in SAS patients.
- To determine the influence of COPD and daytime hypoxemia on RV function in SAS.
Main Methods:
- Isotopic ventriculography to assess right ventricular ejection fraction (RVEF).
- Performed tests included blood gasometry, spirometry, and BMI measurement.
- Patients were grouped based on the presence of COPD and daytime hypoxemia (paO2 < 70 mmHg).
Main Results:
- No significant difference in RVEF between SAS patients with and without COPD.
- A significant difference in RVEF was observed between hypoxemic and normoxemic SAS patients (p < 0.05).
- RVEF was significantly lower in SAS patients with daytime hypoxemia.
Conclusions:
- Daytime hypoxemia is a more significant factor than COPD in worsening RV function in SAS patients.
- Worsening RV function is more prevalent in SAS patients experiencing daytime hypoxemia.
- Findings suggest hypoxemia management is crucial for preventing CCP in SAS.