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Intra-individual variation in creatinine and cystatin C
Niluka Bandaranayake1, Thelma Ankrah-Tetteh, Sethsiri Wijeratne
1Department of Chemical Pathology, St. Thomas' Hospital, London, UK.
Background:
Serum creatinine and cystatin C are measured in the assessment of glomerular filtration rate. Biological variation of an analyte is an important determinant of its usefulness. Intra-individual variation in serum creatinine and cystatin C in healthy subjects was determined in this study.
Methods:
Weekly blood samples were taken from 10 healthy subjects and analysed for creatinine (kinetic Jaffe method) and for cystatin C (by nephelometry).
Results:
Intra-individual variations for serum creatinine and cystatin C were 6.1% and 4.55%, respectively. Index of individuality values were similar for the analytes (0.35 for both).
Conclusion:
Intra-individual variations for serum creatinine and cystatin C were similar in healthy subjects.
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