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Related Experiment Videos

Exercise and heart transplantation. A review.

G Niset1, L Hermans, P Depelchin

  • 1Medical and Surgical Cardiology Department, Université Libre de Bruxelles, Hôpital Erasme, Belgium.

Sports Medicine (Auckland, N.Z.)
|December 1, 1991
PubMed
Summary

Heart transplant recipients experience improved quality of life but reduced aerobic capacity due to cardiac denervation. Endurance training can enhance physical capacity and should be encouraged for these patients.

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Area of Science:

  • Cardiology
  • Exercise Physiology

Background:

  • Heart transplantation significantly improves survival and quality of life for end-stage cardiac disease patients.
  • Despite improvements, heart transplant recipients exhibit reduced maximal aerobic capacity compared to healthy individuals.
  • Cardiac denervation post-transplantation leads to altered resting and exercise hemodynamics.

Purpose of the Study:

  • To investigate the physiological adaptations and exercise capacity in heart transplant recipients.
  • To understand the impact of cardiac denervation on exercise response.
  • To evaluate the role of endurance training in improving physical function.

Main Methods:

  • Analysis of resting and exercise hemodynamics, including heart rate and stroke volume.
  • Assessment of aerobic capacity and metabolic responses during exercise.
  • Review of existing literature on exercise guidelines and training outcomes.

Main Results:

  • Reduced maximal heart rate and stroke volume compared to innervated hearts, leading to early anaerobic metabolism.
  • Altered ventilatory response to exercise (hyperpnoea) is common but not typically the limiting factor.
  • Endurance training demonstrates benefits, including increased peak work output and improved physiological parameters.

Conclusions:

  • Heart transplant recipients have diminished exercise capacity due to denervation, impacting cardiac output response.
  • Endurance training is beneficial and should be encouraged, with exercise prescriptions adapted for denervated hearts.
  • Activities like walking, jogging, cycling, and swimming are feasible and recommended for heart transplant recipients.

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