Related Experiment Video
Updated: Jul 11, 2026
05:31
Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
[Antiphospholipid syndrome and human reproduction]
Carlos G Galindo García1, Francisco J Bernárdez Zapata, Imelda Hernández Marín
1Hospital Español de México Arturo Mundet, Departamento de la Reproduccion Humana, Direccíon de Investigación y Enseñanza.
Ginecologia Y Obstetricia De Mexico
|September 14, 2007
Summary
Antiphospholipid syndrome, an autoimmune disorder, is a significant cause of recurrent pregnancy loss. Early diagnosis and treatment with heparin and aspirin improve outcomes for both mother and baby.
Area of Science:
- Obstetrics and Gynecology
- Immunology
- Hematology
Context:
- Recurrent pregnancy loss (RPL) affects numerous women, with antiphospholipid syndrome (APS) often being an undiagnosed cause.
- APS is an autoimmune condition presenting with diverse clinical manifestations during pregnancy, including miscarriage, hypertensive disorders, and fetal growth restriction.
Purpose:
- To highlight the importance of recognizing antiphospholipid syndrome as a treatable cause of recurrent pregnancy loss.
- To outline diagnostic criteria and therapeutic strategies for APS in pregnancy.
Summary:
- Antiphospholipid syndrome is characterized by specific antibodies (anticardiolipin, lupus anticoagulant) and clinical criteria, crucial for diagnosis.
- Prompt identification and management, including heparin and aspirin, are vital to mitigate severe fetomaternal morbidity and mortality.
- Pregnancy complications associated with APS can extend into the postpartum period, increasing thrombotic risks.
Impact:
- Timely diagnosis and effective management of APS can lead to successful term pregnancies with reduced complications.
- Improved understanding of APS pathophysiology may reveal new therapeutic targets for thrombotic events.
- This knowledge empowers clinicians to better manage pregnant patients with APS, enhancing reproductive outcomes.
Related Concept Videos
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
01:15Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...