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Deep brain stimulation: indications and evidence.

Erlick A C Pereira1, Alexander L Green, Dipankar Nandi

  • 1Oxford Functional Neurosurgery, Nuffield Department of Surgery and Department of Neurological Surgery, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK. eacp@eacp.co.uk

Expert Review of Medical Devices
|September 14, 2007
PubMed
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Deep brain stimulation (DBS) is a proven Parkinson's disease treatment. While effective for various neurological and psychiatric conditions, its application in chronic pain management requires further research and wider adoption.

Area of Science:

  • Neurosurgery
  • Neurology
  • Psychiatry

Background:

  • Deep brain stimulation (DBS) is a minimally invasive neurosurgical technique.
  • It involves electrically stimulating deep brain structures via an implanted pacemaker.
  • DBS is the preferred treatment for Parkinson's disease unresponsive to medication.

Purpose of the Study:

  • To review the development, principles, indications, and effectiveness of DBS.
  • To highlight the established role of DBS in Parkinson's disease.
  • To discuss the challenges and potential for expanded use of DBS in chronic pain management.

Main Methods:

  • Review of existing literature and clinical trial data on DBS.
  • Analysis of current and emerging clinical indications for DBS.

Related Experiment Videos

  • Examination of reasons for limited adoption in chronic pain treatment.

    • Main Results:

    • DBS is a standard treatment for Parkinson's disease with robust evidence.
    • Established indications include movement disorders, psychiatric conditions, epilepsy, and chronic pain.
    • Research suggests potential new uses for hypertension and orthostatic hypotension.
    • DBS for chronic pain is underutilized despite decades of use.

    Conclusions:

    • DBS is a well-established therapy for Parkinson's disease and other conditions.
    • Broader application and evidence appraisal are needed for chronic pain management.
    • Novel approaches to evaluating functional neurosurgery outcomes are proposed.