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Updated: Jul 11, 2026
09:54
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
[Transfusion-related acute lung injury. A case report]
1Service de réanimation chirurgicale, hôpital militaire d'instruction Mohammed-V, Rabat, Maroc.
Annales Francaises D'Anesthesie Et De Reanimation
|September 14, 2007
Summary
Transfusion-related acute lung injury (TRALI) is a lung edema after blood transfusion. A case report highlights TRALI following the first red blood cell unit transfusion in a young woman.
Area of Science:
- Hematology
- Pulmonology
- Immunology
Background:
- Transfusion-related acute lung injury (TRALI) is a severe, often under-recognized, adverse event following blood product transfusion.
- Its etiology and pathophysiology remain debated, with proposed immunological and non-immunological mechanisms.
- TRALI necessitates a predisposing condition, potentially involving leukostasis in pulmonary vasculature.
Observation:
- This case report details a 26-year-old woman who developed TRALI.
- The event occurred shortly after the transfusion of her first unit of red blood cells.
Findings:
- Pulmonary lesions in TRALI result from neutrophil activation and subsequent interaction with pulmonary micro-capillary endothelial cells.
- The specific triggers and predisposing factors in this case warrant further investigation.
Implications:
- Understanding TRALI mechanisms is crucial for improving transfusion safety.
- Early recognition and management strategies for TRALI are essential for patient outcomes.
- This case underscores the importance of vigilance for TRALI even in first-time transfusions.
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