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Updated: Jul 11, 2026

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
Published on: June 21, 2021
Fast and highly efficient solid state oxidation of thiols
Morteza Montazerozohori1, Shiva Joohari, Bahador Karami
1Department of Chemistry, Yasouj University, Yasouj 75918-74831, P. O. Box-35, Iran. mmzohori@mail.yu.ac.ir
Abstract:
A fast and efficient solid state method for the chemoselective room temperature oxidative coupling of thiols to afford their corresponding disulfides using inexpensive and readily available moist sodium periodate as the reagent is described. The reaction was applicable to a variety of thiols giving high yields after short reaction times. Comparison of yield/time ratios of this method with some of those reported in the literature shows the superiority of this reagent over others under these conditions.
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