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The Timed Up and Go test: predicting falls in ALS.

Jacqueline Montes1, Bin Cheng, Beverly Diamond

  • 1Department of Neurology, College of Physicians and Surgeons, The Eleanor and Lou Gehrig MDA/ALS Research Center, Columbia University, New York, NY 10032, USA. jm598@columbia.edu

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
|September 14, 2007
PubMed
Summary

The Timed Up and Go (TUG) test effectively predicts falls in Amyotrophic Lateral Sclerosis (ALS) patients. A TUG time of 14 seconds indicates a 10% fall risk, guiding mobility aid recommendations.

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Area of Science:

  • Neurology
  • Clinical Medicine
  • Rehabilitation Science

Background:

  • Few clinically meaningful measures exist for managing Amyotrophic Lateral Sclerosis (ALS).
  • Falls are frequent, debilitating, and costly complications for ALS patients.
  • The Timed Up and Go (TUG) test measures walking ability and may predict falls.

Purpose of the Study:

  • To evaluate the performance of the TUG test in ALS patients.
  • To determine the TUG test's ability to predict falls in this population.
  • To assess the TUG test's correlation with established ALS outcome measures.

Main Methods:

  • Prospective longitudinal study of 31 ALS patients.
  • Monthly assessments included TUG, ALSFRS-R, forced vital capacity, muscle testing (MMT), and quality of life.

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  • Linear and generalized linear mixed effects models were used for analysis.

    • Main Results:

    • TUG test times increased linearly over six months.
    • TUG time was significantly associated with ALSFRS-R (p<0.001) and MMT scores (p<0.001).
    • The TUG test was the sole predictor of falls (p=0.024); 14 seconds indicated a 10% fall chance.

    Conclusions:

    • The TUG test demonstrates linear decline in ALS, correlates with standard measures, and predicts falls.
    • A TUG time of 14 seconds can guide the recommendation of mobility aids.
    • The TUG test is a valuable tool for managing ALS patients and preventing falls.