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Human methyl parathion poisoning.

Geoffrey K Isbister¹, Katie Mills, Lena E Friberg

¹Tropical Toxinology Unit, Menzies School for Health Research, Charles Darwin University, Australia. geoffrey.isbister@menzies.edu.au

Clinical Toxicology (Philadelphia, Pa.)

|September 14, 2007

Summary

This summary is machine-generated.

Methyl parathion poisoning is rare, but a case showed prolonged enzyme suppression with low human toxicity despite a high rodent LD50. This pesticide may be less toxic in humans than previously thought.

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Area of Science:

Toxicology
Environmental Health
Pharmacokinetics

Background:

Methyl parathion is an extremely hazardous pesticide with established rodent toxicity.
Acute poisoning reports are infrequent despite widespread bans.

Observation:

A 29-year-old male ingested a significant quantity of methyl parathion.
Delayed and prolonged acetylcholinesterase suppression was observed.
Minimal clinical effects were noted in the patient.

Findings:

Methyl parathion absorption was prolonged (30 hours) with low bioavailability.
Enzyme suppression was significant, yet clinical toxicity was low.
Human toxicity appears lower than predicted by rodent LD50 values.

Implications:

Human toxicity of methyl parathion may be lower than parathion.
Further research is needed to reconcile rodent and human toxicity data.
This case highlights the importance of pharmacokinetic analysis in poisoning assessments.