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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
Gastric emptying: a comparison of three methods.
Henning Glerup1, Henrik Bluhme, Gerda E Villadsen
1Department of Internal Medicine, Regionhospital Silkeborg, Denmark. MAHGL@sc.aaa.dk
Scandinavian Journal of Gastroenterology
|September 14, 2007
Summary
The paracetamol absorption test accurately measures gastric emptying in healthy individuals, offering a simpler alternative to gastric emptying scintigraphy. The 13C-acetate breath test did not show comparable results for assessing delayed gastric emptying.
Area of Science:
- Gastroenterology
- Nuclear Medicine
- Pharmacokinetics
Background:
- Delayed gastric emptying is clinically relevant, particularly in diabetes.
- Accurate and accessible methods for measuring gastric emptying are needed.
- Gastric emptying scintigraphy (GES) is the gold standard but is complex and expensive.
Purpose of the Study:
- To compare the accuracy of the paracetamol absorption test and the 13C-acetate breath test against GES for measuring liquid gastric emptying.
- To evaluate simpler, more accessible methods for assessing gastric emptying.
Main Methods:
- Simultaneous measurement of gastric emptying in 10 healthy subjects using GES, paracetamol absorption test, and 13C-acetate breath test.
- Generation of gastric emptying time-retention curves for each method.
- Comparison of results at 75%, 50%, and 25% retention quartiles.
Main Results:
- The paracetamol absorption test demonstrated strong agreement with GES (p=0.95).
- The 13C-acetate breath test, using Wagner-Nelson correction, showed statistically significant underestimation compared to GES (p<0.01).
Conclusions:
- The paracetamol absorption test is a viable and comparable alternative to GES for assessing liquid gastric emptying in healthy subjects.
- The 13C-acetate breath test, in its current application, is not comparable to GES for this purpose.
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