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Dynamic conformational behavior and molecular interaction discrimination of DNA/binder complexes by single-chain

Wei-Hua Huang1, Anatoly A Zinchenko, Cyril Pawlak

  • 1Department of Chemistry, Ecole Normale Superieure, 24 rue Lhomond, 75005 Paris, France.

Chembiochem : a European Journal of Chemical Biology
|September 15, 2007
PubMed
Abstract

No abstract available in PubMed .

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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...

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