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Updated: Jul 11, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
AutoAbSC.Org -- Autoantibody Standardization Committee in 2006
Edward K L Chan1, Marvin J Fritzler, Allan Wiik
1Department of Oral Biology, University of Florida, Health Science Center, 1600 SW Archer Road, Gainesville, FL 32610-0424, USA. echan@ufl.edu
The Autoantibody Standardization Committee provides essential reference reagents for autoimmune disease research. These critical standards ensure accuracy in academic, clinical, and industrial laboratories, with ongoing efforts to expand availability.
Area of Science:
- Immunology
- Clinical Chemistry
Background:
- The need for standardized autoimmune sera was identified in the early 1980s for reliable laboratory diagnostics.
- Standardization is crucial for accuracy in autoimmune disease research and clinical testing.
Purpose of the Study:
- To establish and maintain a resource for reference human autoimmune sera.
- To support academic, clinical, and industrial laboratories through standardized reagents.
Main Methods:
- Establishment of the Autoantibody Standardization Committee (AutoAbSC).
- Distribution of 14 free reference reagents via the Centers for Disease Control and Prevention (CDC).
- Development of the AutoAbSC.Org website for community communication and mission advancement.
Main Results:
- 14 reference reagents are currently available.
- A dedicated website (AutoAbSC.Org) has been launched.
- The committee continues its mission to standardize autoantibody testing.
Conclusions:
- The Autoantibody Standardization Committee successfully provides critical reference materials.
- Accessible reference reagents and online communication enhance autoantibody standardization efforts.
- Ongoing commitment to supporting laboratories in autoantibody detection and research.
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