Related Experiment Video
Updated: Jan 13, 2026

Isolation of Exosome-Enriched Extracellular Vesicles Carrying Granulocyte-Macrophage Colony-Stimulating Factor from Embryonic Stem Cells
Published on: November 11, 2021
Potential uses of recombinant human granulocyte-macrophage colony-stimulating factor in children
1Department of Hematology/Oncology, St. Jude Children's Research Hospital, College of Medicine, University of Tennessee, Memphis 38101.
Abstract:
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a glycoprotein necessary for the growth, differentiation, and function of cells of the granulocyte-macrophage lineage. This agent has been molecularly cloned and expressed in bacteria, yeast, and mammalian cell lines, providing a limitless source of the pure human protein for use in children. Here, we briefly review the discovery, biologic characterization, gene identification and cloning, and clinical experience to date with this new agent, focusing where possible on the use of recombinant GM-CSF in children.
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