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Related Experiment Videos

Embryologic development of flexion creases.

S Kimura1

  • 1First Department of Anatomy, Nihon University School of Dentistry, Tokyo, Japan.

Birth Defects Original Article Series
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Flexion creases in hands and feet develop under genetic influence, potentially linked to fetal hand movement and volar pads. Understanding their origin is key for diagnosing congenital malformations.

Area of Science:

  • Developmental Biology
  • Embryology
  • Medical Genetics

Background:

  • Palmar, plantar, and digital flexion creases are significant in medical practice due to their association with congenital malformations.
  • While the timing of flexion crease development is known, their precise origin remains unclear.
  • Existing evidence for crease development mechanisms is largely indirect.

Purpose of the Study:

  • To explore the embryonal development and origin of flexion creases.
  • To establish the significance of crease development in medical practice.
  • To investigate the interplay between genetic factors, fetal movement, and crease formation.

Main Methods:

  • Review of existing literature on flexion crease development.
  • Analysis of indirect evidence related to fetal hand movement and malformations.

Related Experiment Videos

  • Consideration of morphologic relationships with fetal volar pads.

    • Main Results:

    • Flexion crease development is influenced by genetic factors and occurs in close relation to fetal volar pads.
    • Early genetic and environmental factors affecting hand development can impact crease formation.
    • The timing of crease appearance correlates with fetal hand and digital movement.

    Conclusions:

    • Flexion creases likely develop under genetic influences, closely associated with fetal volar pads.
    • Factors affecting early hand development, including genetic and environmental influences, can alter crease formation.
    • Further experimental studies in nonhuman fetuses are needed to definitively resolve the origin of flexion creases.