Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perspectives and future on testing for abuse liability in humans.

J Camí1

  • 1Institut Municipal d'Investigació Mèdica, Barcelona, Spain.

British Journal of Addiction
|December 1, 1991
PubMed
Summary

Drug abuse liability testing is crucial for public health and safer medications. Further research and real-world data are needed to refine human testing methods for better drug development and regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atomically resolved phase transition of fullerene cations solvated in helium droplets.

Nature communications·2016
Same author

Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 2 h apart.

Psychopharmacology·2012
Same author

Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics.

Psychopharmacology·2004
Same author

[Evaluation of biomedical research].

Medicina clinica·2001
Same author

Modulation of rate of onset and intensity of drug effects reduces abuse potential in healthy males.

Drug and alcohol dependence·2001
Same author

[Prioritization of biomedical research: implications for investigation in public health and health services].

Gaceta sanitaria·2001

Area of Science:

  • Pharmacology
  • Public Health
  • Drug Development

Background:

  • Drug abuse liability testing is essential for public health.
  • It aids in promoting proper therapeutic use and developing safer drugs.
  • Current animal and human testing methods are useful but imperfect predictors of abuse.

Purpose of the Study:

  • To highlight the importance of drug abuse liability testing.
  • To suggest improvements for human drug abuse liability testing procedures.
  • To emphasize the need for systematic use of these methods in drug development and regulation.

Main Methods:

  • Review of existing drug abuse liability testing procedures.
  • Analysis of factors influencing actual drug abuse.
  • Consideration of epidemiological data as a benchmark.

Main Results:

  • Drug abuse liability testing offers significant public health benefits.
  • Existing methods, while valuable, require further refinement.
  • Individual and subpopulation differences in response to testing need more investigation.

Conclusions:

  • Human drug abuse liability testing methods should be systematically implemented.
  • Epidemiological data should serve as the gold standard for validating testing methods.
  • Enhanced testing will guide appropriate drug development, regulation, and marketing.

Related Experiment Videos