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Updated: Jul 11, 2026
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Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
[IgG-kappa type multiple myeloma with cytoplasmic crystalline inclusions]
Chiharu Kobayashi1, Juichi Tanabe, Mayako Aoki
1Department of Clinical Laboratory, Fujieda Municipal General Hospital.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|September 18, 2007
Summary
Anemia in an 82-year-old male was linked to atypical plasma cells containing crystalline inclusions. These inclusions, identified as abnormal IgG-kappa immunoglobulin, suggest a synthesis and secretion disorder.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Presents a case of an 82-year-old male with severe anemia (Hb 6.9 g/dL).
- Highlights the detection of monoclonal IgG of the kappa type in serum.
Observation:
- Bone marrow examination revealed 38.9% atypical plasma cells.
- These plasma cells contained crystalline inclusions, positive for acid phosphatase, IgG-kappa, and CD138, but negative for MPO, PAS, and Congo-Red.
Findings:
- Electron microscopy characterized the inclusions as rod-shaped, rhomboid, or rectangular crystals with longitudinal striations.
- Crystals were observed within the rough-surfaced endoplasmic reticulum and surrounded by ribosomes.
Implications:
- Suggests an underlying abnormality in immunoglobulin synthesis and/or secretion.
- Contributes to understanding plasma cell disorders and the nature of crystalline inclusions.
