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[The anticonvulsant activity of digoxin in rats of different ages and in mice]
Abstract:
The anticonvulsant activity of digoxin was studied on rats of different ages and mice. Cramps were simulated by using electroshock or a subcutaneous administration of bemegrid or corasol. The effect of digoxin (in the doses amounting to 1/10 or 1/2 of LD50) on the time of the onset of cramps, the duration of tonic and clonic phases as well as the number of the deceased animals was evaluated. The detected anticonvulsant effect of digoxin is explained by its influence on the activity of the membrane Na+, K+, ATP-ase and K+ conductivity.
Insights
Digoxin demonstrates anticonvulsant properties in animal models, reducing seizure severity and mortality. This effect is linked to its impact on membrane Na+, K+-ATPase activity and potassium ion conductivity.
Area of Science:
- Pharmacology and Toxicology
- Neuroscience
Context:
- Investigating novel therapeutic applications for existing drugs.
- Understanding the mechanisms of seizure disorders.
Purpose:
- To evaluate the anticonvulsant activity of digoxin.
- To elucidate the underlying biochemical mechanisms of digoxin's effects.
Summary:
- Digoxin was tested for anticonvulsant effects in rats and mice using electroshock, bemegride, and corasol-induced seizures.
- The study assessed digoxin's impact on seizure onset, duration of tonic-clonic phases, and mortality at doses up to 1/2 LD50.
- A significant anticonvulsant effect was observed, attributed to digoxin's influence on membrane Na+, K+-ATPase activity and K+ conductivity.
Impact:
- Provides evidence for digoxin's potential as an anticonvulsant agent.
- Offers insights into the role of ion transport in seizure activity.
- Suggests a novel therapeutic avenue for managing seizure disorders.