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Assays for Validating Histone Acetyltransferase Inhibitors
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Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors

Arturo J Vegas1, James E Bradner, Weiping Tang

  • 1Howard Hughes Medical Institute, Chemistry and Chemical Biology, Harvard University, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.

Angewandte Chemie (International Ed. in English)
|September 18, 2007
PubMed
Abstract

No abstract available in PubMed .

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...