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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
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Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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Diabetic Nephropathy01:28

Diabetic Nephropathy

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Acute Kidney Injury II: Pathophysiology

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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[Nephrogenic systemic fibrosis].

István Pintér1, Katalin Vágási, István Wittmann

  • 1Pécsi Tudományegyetem, Altalános Orvostudományi Kar II. Belgyógyászati Klinika és Nefrológiai Centrum Pécs Pacsirta u. 1. 7624.

Orvosi Hetilap
|September 18, 2007
PubMed
Summary

Nephrogenic systemic fibrosis (NSF) is a rare condition linked to gadolinium MRI contrast in patients with kidney disease. While no cure exists, treatments like kidney transplants and plasmapheresis show potential for managing this serious fibrosis.

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Area of Science:

  • Nephrology
  • Radiology
  • Dermatology

Context:

  • Nephrogenic systemic fibrosis (NSF), previously known as nephrogenic fibrosing dermopathy, is a rare but serious condition.
  • NSF primarily affects patients with severe renal impairment, particularly those undergoing dialysis.
  • The condition is strongly associated with exposure to gadolinium-based contrast agents used in Magnetic Resonance Imaging (MRI).

Purpose:

  • To describe the clinical characteristics, etiology, and potential management strategies for nephrogenic systemic fibrosis.
  • To highlight the association between gadolinium contrast agents and NSF in patients with renal disease.
  • To review the limited therapeutic options and their reported outcomes in NSF cases.

Summary:

  • NSF is characterized by progressive fibrosis, typically starting in the extremities and potentially affecting multiple organs including lungs, liver, heart, and muscles.
  • The disease can progress rapidly and have a fatal outcome in approximately 5% of cases with multi-organ involvement.
  • Current treatment lacks evidence-based protocols; however, renal transplantation, plasmapheresis, and extracorporeal photopheresis have shown some amelioration or remission in isolated instances.

Impact:

  • This information is crucial for radiologists and nephrologists to identify at-risk patients and consider alternative contrast agents.
  • Understanding the association aids in patient counseling and risk mitigation strategies.
  • Highlights the need for further research into effective, evidence-based treatments for NSF.