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Clinical grading of atopic keratoconjunctivitis
Margarita Calonge1, José M Herreras
1Ocular Immunology Clinical Unit and Ocular Surface Research Group, IOBA (Institute of Applied Ophthalmobiology), University of Valladolid, Valladolid, Spain. calonge@ioba.med.uva.es
Current Opinion in Allergy and Clinical Immunology
|September 18, 2007
Summary
A new classification system for atopic keratoconjunctivitis (AKC) is proposed, grading disease severity. This aims to standardize patient selection for clinical trials and advance treatments for this chronic ocular allergy.
Area of Science:
- Ophthalmology
- Allergy Immunology
- Dermatology
Background:
- Atopic keratoconjunctivitis (AKC) is a severe ocular complication in some atopic dermatitis patients.
- AKC presents a wide range of clinical severity, complicating patient selection for research.
- Current literature lacks a standardized classification system for AKC.
Purpose of the Study:
- To propose a novel classification system for atopic keratoconjunctivitis (AKC).
- The classification is based on grading clinical severity, symptoms, and signs.
- To establish a common language for AKC research and clinical trials.
Main Methods:
- Review of recent reports on AKC pathogenesis and clinical manifestations.
- Development of a severity-grading system for AKC symptoms and signs.
- Proposal of a new definition and classification for AKC.
Main Results:
- Recent research has improved understanding of AKC pathogenesis and identified potential therapies.
- No prior classification system for AKC based on clinical severity was identified.
- A new classification system for AKC is presented, based on graded clinical severity.
Conclusions:
- The proposed AKC classification aims to standardize patient cohorts for clinical studies.
- This system facilitates discussion among researchers in ocular surface inflammation.
- A unified classification is crucial for developing effective AKC treatments and achieving regulatory approval.
