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Delayed presentation of pulmonary polymethylmethacrylate emboli after percutaneous vertebroplasty
Youssef Abdul-Jalil1, Joerg Bartels, Olaf Alberti
1Department of Neurosurgery, Asklepios Klinik Schildautal Seesen, Germany. abdul-jalil@gmx.de
Study Design:
Literature review concerning pulmonary embolism of polymethylmethacrylate (PMMA) material following percutaneous vertebroplasty and a report on 2 new cases.
Objective:
To inform clinicians about delayed clinical manifestation of pulmonary embolism of polymethylmethacrylate material after percutaneous vertebroplasty, pathophysiology, precautions, and therapeutic management of this complication.
Summary Of Background Data:
Percutaneous vertebroplasty is a minimal invasive intervention used to treat vertebral fractures, which yields good therapeutic results and rarely produces complications. Nevertheless, serious complications may occur. Pulmonary PMMA embolism, which has been recently reported in some cases, is one of these.
Methods And Results:
We report on 2 cases of pulmonary embolism of PMMA material after percutaneous vertebroplasty. In the case of a 45-year-old female patient, symptoms of pulmonary embolism arose with a delay of 3 days following percutaneous vertebroplasty. A therapy with low-molecular-weight heparin, Enoxaparin, enabled recovery from pulmonary failure. The second case occurred without detection of any cement leakage into the paravertebral venous system, neither intraoperatively nor perioperatively. The existence of PMMA in pulmonary vessels was detected 1 year later and remained asymptomatic.
Conclusion:
These 2 cases allow us to conclude that the risk of pulmonary embolism of PMMA might be underestimated. We propose routine chest radiograph following every vertebroplasty, in order to detect pulmonary PMMA embolism and thereby prevent serious delayed cardiopulmonary failures.
Insights
Pulmonary embolism of polymethylmethacrylate (PMMA) material can occur after percutaneous vertebroplasty, sometimes with delayed symptoms. Early detection via chest radiography may prevent serious cardiopulmonary complications.
Area of Science:
- Interventional Radiology
- Pulmonary Medicine
- Neurosurgery
Background:
- Percutaneous vertebroplasty is a common procedure for vertebral fractures with generally good outcomes.
- Serious complications, though rare, can arise, including pulmonary embolism of polymethylmethacrylate (PMMA).
- This study reviews the literature and presents two new cases of PMMA pulmonary embolism.
Observation:
- One patient presented with delayed pulmonary embolism symptoms three days post-procedure, successfully treated with heparin.
- The second case involved asymptomatic PMMA pulmonary embolism detected one year later, with no intraoperative or perioperative cement leakage identified.
- These cases highlight the potential for delayed and asymptomatic presentations of PMMA pulmonary embolism.
Findings:
- The risk of pulmonary embolism of PMMA material following percutaneous vertebroplasty may be underestimated.
- Clinical manifestations can be delayed, presenting days to over a year after the procedure.
- Pulmonary PMMA embolism can occur even without detectable cement leakage during or immediately after vertebroplasty.
Implications:
- Clinicians should be aware of the possibility of delayed pulmonary embolism of PMMA material after percutaneous vertebroplasty.
- Routine chest radiography following vertebroplasty is proposed to aid in early detection of pulmonary PMMA embolism.
- Prompt diagnosis and management are crucial to prevent severe delayed cardiopulmonary complications.
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