Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Pulmonary Tuberculosis V

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Trichomoniasis

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Between insects and birds: molecular evidence of Bartonella henselae DNA in Rhodnius prolixus (Stål, 1859) from an insectary and Cairina moschata (Linnaeus, 1758) ducks used as triatomine blood meal source.

Revista do Instituto de Medicina Tropical de Sao Paulo·2026

Same author

Sweet syndrome with reactive lymphadenopathy mimicking metastatic disease in an <i>SDHB</i>-mutated abdominal paraganglioma.

JCEM case reports·2026

Same author

Molecular identification of Bartonella henselae in dogs with clinical suspicion of visceral leishmaniasis.

Revista do Instituto de Medicina Tropical de Sao Paulo·2026

Same author

Sarcoidosis-like cutaneous lesions in paracoccidioidomycosis: four case reports and review of the literature.

Anais brasileiros de dermatologia·2026

Same author

Adipophilin-stained lipid droplets and M2 macrophages in Jorge Lobo's disease.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2025

Same author

Managing leprosy reactions with secukinumab: Insights from a case series.

Revista da Sociedade Brasileira de Medicina Tropical·2025

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

Donovanosis treated with thiamphenicol.

Walter Belda¹, Paulo Eduardo Neves Ferreira Velho, Marcelo Arnone

¹Department of Dermatology, School of Medicine, University of São Paulo, Brazil.

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases

|September 18, 2007

Summary

This summary is machine-generated.

Thiamphenicol effectively healed donovanosis lesions in eight out of ten patients, including those with HIV. This antibiotic shows promise as a safe and cost-effective treatment for donovanosis.

More Related Videos

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Published on: October 25, 2024

Related Experiment Videos

Last Updated: Jul 11, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Published on: October 25, 2024

Area of Science:

Infectious Diseases
Tropical Medicine
Dermatology

Background:

Donovanosis, a chronic granulomatous sexually transmitted infection, is caused by Klebsiella granulomatis.
Treatment options for donovanosis can be limited, and drug resistance is a growing concern.
Effective and accessible management strategies are crucial, particularly in resource-limited settings.

Purpose of the Study:

To evaluate the efficacy and safety of thiamphenicol in treating donovanosis.
To assess the treatment outcomes in both HIV-negative and HIV-positive patients.

Main Methods:

A prospective study involving ten patients diagnosed with donovanosis.
Patients received a two-week course of thiamphenicol.
Clinical outcomes, including lesion healing and adverse events, were monitored.

Main Results:

Lesion healing was observed in eight out of ten patients (80% efficacy).
Two of the successfully treated patients were co-infected with HIV.
Thiamphenicol was generally well-tolerated, indicating a favorable safety profile.

Conclusions:

Thiamphenicol demonstrates significant efficacy and a good safety profile for donovanosis management.
Its cost-effectiveness makes it a valuable therapeutic option, especially in endemic areas.
Further randomized controlled trials are warranted to confirm these findings and establish thiamphenicol as a standard treatment.