Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue engineered heart valves based on human cells.

Dörthe Schmidt1, Simon P Hoerstrup

  • 1Division of Regenerative Medicine (Tissue Engineering and Cell Transplantation), Department of Surgical Research and Clinic for Cardiovascular Surgery, University Hospital, Zurich, Switzerland.

Swiss Medical Weekly
|September 19, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insights Into the Natural History of Recurrent Myocarditis, A Multicenter International Study (Re-Myo Study).

Journal of the American Heart Association·2026
Same author

Small Diameter Vascular Grafts Made in Minutes.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Cardiovascular stent technologies for coronary and valvular heart disease: the potential of 3D printing for stent fabrication.

Nature reviews. Cardiology·2026
Same author

MSC Origin and Biomechanical Conditioning Determine ECM Maturation in Tissue-Engineered Matrix.

Biomedicines·2026
Same author

T cells in acute and chronic myocarditis: from diagnosis to treatment.

European heart journal·2026
Same author

Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers?

JACC. Basic to translational science·2026
Same journal

Metamizole-induced agranulocytosis: utilisation trends, pharmacovigilance signals and regulatory risk-minimisation in Switzerland.

Swiss medical weekly·2026
Same journal

Female genital mutilation/cutting and risk of obstetric anal sphincter injury at delivery.

Swiss medical weekly·2026
Same journal

Drug prescription before and after implementation of a CPOE system on the Paediatric Intensive Care Unit: a quality improvement study.

Swiss medical weekly·2026
Same journal

Trends in health- and lifestyle-related aspects in women of childbearing age: analysis of Swiss Health Survey data between 1992 and 2022.

Swiss medical weekly·2026
Same journal

Microplastics in the air and potential health risks - a narrative review.

Swiss medical weekly·2026
Same journal

Potentially inappropriate medication: prevalence, risk of hospitalisation and associated healthcare costs in the general older population of Switzerland.

Swiss medical weekly·2026
See all related articles

Tissue engineering offers living heart valve replacements using autologous cells. This review examines various human cell sources for extracellular matrix production in cardiovascular tissue regeneration.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Valvular heart disease poses a significant global health burden.
  • Current valve replacements (mechanical, biological) have notable drawbacks.
  • Tissue engineering seeks autologous, living alternatives for heart valve repair and growth.

Purpose of the Study:

  • To review human cell sources for cardiovascular tissue engineering.
  • To assess cell phenotypes and extracellular matrix production capabilities.
  • To evaluate suitability for creating neo-heart valve tissue.

Main Methods:

  • Review of scientific literature on cell sources for tissue engineering.
  • Analysis of cell phenotypes from various human tissues.

Related Experiment Videos

  • Assessment of extracellular matrix (ECM) production potential.

    • Main Results:

    • Identified potential cell sources: vessels, bone marrow, umbilical cord, chorionic villi.
    • Highlighted differences in cell phenotypes and ECM synthesis.
    • Emphasized the need for cell selection based on tissue engineering requirements.

    Conclusions:

    • Autologous cell sources show promise for engineered heart valves.
    • Optimizing cell selection is crucial for successful neo-tissue development.
    • Tissue engineering offers a regenerative alternative to current valve replacement therapies.