Imaging of penile neoplasm

Penile malignancies are rare, accounting for less than 1% of all male malignancy in the United States. The diagnosis can be very devastating psychologically to patients and often presents a challenge for physicians to accurately diagnose and treat these neoplasms. Clinical examination is known to have certain limitations and cross-sectional imaging techniques are increasingly utilized. Knowledge in imaging characteristics of the normal anatomy of the penis, vascular supply, lymphatic drainage, and pathology of penile malignancy is essential for an accurate staging. In this article, normal anatomy of the penis is briefly discussed and is followed by a review of multiple imaging approaches for characterization of the primary tumor and nodal staging.