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Updated: Jul 11, 2026
08:54
Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Emerging therapeutic agents for onychomycosis.
Gérald E Piérard1, Jorge E Arrese, Pascale Quatresooz
1CHU Sart Tilman, Department of Dermatopathology, B-4000 Liège, Belgium. Gerald.pierard@ulg.ac.be
Expert Opinion on Emerging Drugs
|September 19, 2007
Summary
Onychomycosis, a common fungal nail infection, has limited effective treatments. Research focuses on new antifungals and delivery methods for better cure rates in patients.
Area of Science:
- Mycology
- Dermatology
- Pharmaceutical Sciences
Background:
- Onychomycosis is the most common fungal infection, especially in older adults.
- Dermatophytes, molds, and yeasts cause onychomycosis.
- Limited new antifungal drug development in the past decade.
Purpose of the Study:
- To review current treatment options for onychomycosis.
- To discuss the limitations of existing therapies.
- To highlight emerging strategies in antifungal drug development for nail infections.
Main Methods:
- Literature review of current and emerging treatments for onychomycosis.
- Analysis of antifungal drug classes, including azoles and allylamines.
- Examination of novel drug delivery systems and new antifungal discovery.
Main Results:
- Oral therapies offer better outcomes than topical treatments but lack durable cure rates.
- Azoles and allylamines remain primary treatments.
- New derivatives and formulations of azoles show promise.
Conclusions:
- Current onychomycosis treatments have limitations in efficacy and durability.
- Future strategies involve novel delivery technologies and the discovery of new antifungal agents.
- Improved risk-benefit profiles and enhanced nail penetration are key development goals.
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