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Related Experiment Videos

Comparison of Indian reference equations for spirometry interpretation.

Ashutosh N Aggarwal1, Dheeraj Gupta, Surinder K Jindal

  • 1Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. ashutosh@indiachest.org

Respirology (Carlton, Vic.)
|September 19, 2007
PubMed
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Regional lung function test reference equations in India show significant differences. North, west, and south Indian spirometry equations are not interchangeable for interpreting results in north Indian patients, impacting clinical decisions.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Clinical Diagnostics

Background:

  • India's large population necessitates unified lung function test interpretation standards.
  • Existing regional spirometry reference equations (north, west, south) may yield varied results.
  • This study addresses the clinical utility of different Indian spirometry equations.

Purpose of the Study:

  • To compare spirometry interpretation using north, west, and south Indian reference equations in north Indian patients.
  • To assess the clinical significance of differences in lower limit of normal (LLN) values across regions.
  • To determine if a single set of equations can be applied nationwide.

Main Methods:

  • Analysis of 27,383 spirometric records from patients aged 16-65 years.

Related Experiment Videos

  • Comparison of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV(1)), and FEV(1)%FVC values derived from three regional equations.
  • Evaluation of discrepancies in LLN across age and height strata.

    • Main Results:

    • Significant discordance observed between north and west (22.1%) and north and south (12.9%) Indian equations.
    • North Indian patients with abnormal spirometry were often misclassified as normal using west or south Indian equations.
    • South and west Indian equations showed underprediction of LLN for FVC and FEV(1) in various demographic groups.

    Conclusions:

    • North, west, and south Indian reference equations produce non-equivalent spirometry interpretations for north Indian patients.
    • Regional variations necessitate careful consideration when applying spirometry reference equations across India.
    • Current regional equations are not interchangeable for accurate lung function assessment nationwide.