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Serum insulin-like growth factor 1 concentrations in the developing rhesus monkey
1Department of Pediatrics, University of California, School of Medicine, Davis 95616.
Insights
Serum insulin-like growth factor 1 (IGF-1) levels in rhesus monkeys show developmental changes, rising at puberty and differing between sexes. This pattern mirrors human IGF-1 development.
Area of Science:
- Primate endocrinology
- Developmental biology
- Comparative physiology
Background:
- Serum insulin-like growth factor 1 (IGF-1) plays a crucial role in growth and development.
- Understanding IGF-1 dynamics in non-human primates can provide insights into human physiology.
- Rhesus monkeys are a relevant model organism for studying primate development.
Purpose of the Study:
- To investigate the developmental trajectory of serum IGF-1 concentrations in rhesus monkeys.
- To compare IGF-1 levels across different age groups, sexes, and physiological states (e.g., pregnancy).
- To establish the similarity of IGF-1 patterns between rhesus monkeys and humans.
Main Methods:
- Cross-sectional and longitudinal studies were conducted on rhesus monkeys.
- Serum IGF-1 concentrations were measured.
- Data were analyzed to identify patterns related to age, sex, and body weight.
Main Results:
- Serum IGF-1 concentrations were lower in infant rhesus monkeys, with a notable increase at puberty.
- Female rhesus monkeys generally had lower IGF-1 levels than males, except during pregnancy.
- A positive correlation between IGF-1 levels and body weight was observed in males.
- Longitudinal data from six animals confirmed the age-dependent nature of IGF-1 values.
Conclusions:
- Rhesus monkeys exhibit a developmental pattern of serum IGF-1 concentrations that closely resembles that of humans.
- These findings support the use of rhesus monkeys as a model for studying human growth and endocrine development.
- Sex and pubertal status significantly influence IGF-1 levels in this primate model.
Abstract:
We studied the developmental pattern of serum IGF-1 concentrations in the rhesus monkey in cross-sectional and longitudinal manners. Values were lower in infants with a significant rise at the onset of puberty. Females values were lower than males except for pregnant females. There was a correlation of IGF-1 values with body weight in the males. Longitudinal study of six animals proved this age dependence of IGF-1 values. The rhesus monkey has a pattern of serum IGF-1 concentrations similar to that of the human being.