Related Experiment Videos
Normal serum biochemical and hematological parameters in Macaca fascicularis
G Perretta1, A Violante, M Scarpulla
1Istituto di Medicina Sperimentale, C.N.R., Rome, Italy.
Journal of Medical Primatology
|September 1, 1991
Summary
This study in cynomolgus macaques found no significant sex differences in biochemical values. Food intake significantly affected several biochemical and hematological parameters in these non-human primates.
Area of Science:
- Primate physiology
- Comparative hematology
- Clinical biochemistry
Background:
- Establishing reference ranges for non-human primates is crucial for preclinical research.
- Cynomolgus macaques are widely used models, but physiological variations need characterization.
Purpose of the Study:
- To analyze the effects of age, sex, and pregnancy on cynomolgus macaque hematology and biochemistry.
- To compare biochemical and hematological parameters between fasted and fed states.
Main Methods:
- Analysis of hematological and biochemical data from a population of cynomolgus macaques.
- Comparison of parameters across different age groups, sexes, and physiological states (pregnancy, fed vs. fasted).
Main Results:
- No significant sex-based differences were observed in biochemical values.
- Male hematological parameters showed no age-related changes.
- Most female values remained within normal ranges during pregnancy.
- Significant alterations in parameters like ALT, glucose, CPK, LDH, monocytes, eosinophils, basophils, hemoglobin, MCV, MCHC, and MCH were noted between fed and fasted states.
Conclusions:
- Sex and age have minimal impact on most measured biochemical and hematological parameters in cynomolgus macaques.
- Pregnancy generally does not cause significant deviations from normal ranges.
- Food intake is a critical factor influencing numerous biochemical and hematological values, necessitating standardized conditions for accurate assessment.