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Bioimaging in the mid-infrared using an organometallic carbonyl tag

Kien Voon Kong1, Wee Chew, Lina Hsiu Kim Lim

  • 1Department of Chemistry, National University of Singapore, Kent Ridge, Singapore 119260.

Bioconjugate Chemistry
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PubMed

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...