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Updated: Jul 11, 2026
Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
Published on: May 26, 2011
The DOMON domains are involved in heme and sugar recognition
Lakshminarayan M Iyer1, Vivek Anantharaman, L Aravind
1National Center for Biotechnology Information, National Library of Medicine and National Institute of Health, Bethesda, MD 20894, USA.
Unlabelled:
We expand the functionally uncharacterized DOMON domain superfamily to identify several novel families, including the first prokaryotic representatives. Using several computational tools we show that it is involved in ligand binding--either as heme- or sugar-binding domains. We present evidence that the DOMON domain along with the DM13 domain comprises a novel electron-transfer system potentially involved in oxidative modification of animal cell-surface proteins. Other novel versions might function as sugar sensors of histidine kinases of bacterial two component systems.
Supplementary Information:
Supplementary data are available at Bioinformatics online and also at ftp://ftp.ncbi.nih.gov/pub/aravind/domon/.
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