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Updated: Jul 11, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

Fyn regulates the duration of TCR engagement needed for commitment to effector function

Andrew Filby1, Benedict Seddon, Joanna Kleczkowska

  • 1Division of Molecular Immunology, Medical Research Council, National Institute for Medical Research, The Ridgeway, London, United Kingdom.

Journal of Immunology (Baltimore, Md. : 1950)
|September 20, 2007
PubMed
Summary

T cell activation requires sustained signaling. This study reveals the Src family kinase Fyn opposes T cell proliferation and IL-2 production, acting as a brake on T cell receptor signaling.

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