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Related Experiment Videos

Post-exposure vaccination improves gammaherpesvirus neutralization.

Laurent Gillet1, Janet S May, Philip G Stevenson

  • 1Division of Virology, Department of Pathology, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom.

Plos One
|September 20, 2007
PubMed
Summary
This summary is machine-generated.

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Vaccinating herpesvirus carriers with a gH/gL fusion protein enhances virus neutralization. This strategy may reduce herpesvirus (MHV-68) transmission by improving antibody responses against viral membrane fusion.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Herpesvirus carriers transmit infections despite producing antibodies, indicating suboptimal immune responses.
  • Current antibodies against murine gamma-herpesvirus-68 (MHV-68) block cell binding but enhance Fc receptor-dependent myeloid cell infection, leaving viral membrane fusion unimpeded.

Purpose of the Study:

  • To investigate if vaccinating carriers can improve virus neutralization.
  • To determine if targeting the gH/gL viral component can enhance antibody-mediated control of herpesvirus infection.

Main Methods:

  • Vaccination of MHV-68 carriers with a gH/gL fusion protein.
  • In vitro and in vivo assessment of virus neutralization capacity.
  • Analysis of antibody responses targeting viral membrane fusion.

Related Experiment Videos

Main Results:

  • gH/gL-specific antibodies effectively block both Fc receptor-independent and Fc receptor-dependent MHV-68 infections.
  • Vaccination with gH/gL fusion protein significantly improved virus neutralization in carriers.
  • Enhanced neutralization was observed both in vitro and in vivo.

Conclusions:

  • Targeting the gH/gL component with vaccination can elicit potent neutralizing antibodies against herpesviruses.
  • Vaccinating carriers with gH/gL fusion protein represents a promising strategy to improve viral control and reduce transmission.