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Reconstruction of N-acetyltransferase 2 haplotypes using PHASE.

Klaus Golka1, Meinolf Blaszkewicz, Mirabutaleb Samimi

  • 1Institute for Occupational Physiology at the University of Dortmund (IfADo), Dortmund, Germany. golka@ifado.de

Archives of Toxicology
|September 20, 2007
PubMed
Summary

Statistical haplotype reconstruction using PHASE v2.1.1 resolved ambiguous N-acetyltransferase 2 (NAT2) genotyping results. This method accurately determined NAT2 haplotypes in over 99.9% of cases, crucial for understanding drug metabolism and disease risk.

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