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Related Experiment Video

Updated: Jul 11, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Macrodystrophia lipomatosa extending into the upper abdomen.

Traci R Fritz¹, Leonard E Swischuk

¹The University of Texas Medical Branch, Galveston, TX 77555-0365, USA.

Pediatric Radiology

|September 20, 2007

Summary

Macrodystrophia lipomatosa, a rare condition, involves excessive fatty tissue growth. This case highlights its unusual abdominal extension in an infant, presenting unique diagnostic and management challenges.

Area of Science:

Medical case report
Pediatric rare diseases
Clinical genetics

Background:

Macrodystrophia lipomatosa is a rare congenital disorder characterized by progressive, non-inherited overgrowth of adipose and fibrous tissue.
Typically affects the limbs, leading to asymmetry and functional impairment.
Intra-abdominal involvement is exceptionally uncommon, making it a diagnostic challenge.

Observation:

A case of macrodystrophia lipomatosa in an infant is presented.
The infant exhibited typical limb abnormalities alongside an abdominal mass.
Histopathological examination confirmed hypertrophied lipomatous tissue extending into the abdomen and abdominal wall.

Findings:

This case represents a rare manifestation of macrodystrophia lipomatosa with significant intra-abdominal and abdominal wall adipose tissue extension.

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The combination of limb and abdominal involvement underscores the potential systemic nature of the condition.

Literature review confirms the rarity of such extensive intra-abdominal adipose proliferation in macrodystrophia lipomatosa.

Implications:

Highlights the importance of considering intra-abdominal pathology in infants with macrodystrophia lipomatosa, even with typical limb findings.
Suggests the need for advanced imaging to evaluate for abdominal extension in affected infants.
Further research into the genetic and developmental mechanisms underlying atypical presentations of macrodystrophia lipomatosa is warranted.