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Updated: Jul 11, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Modified Julia fluoroolefination: selective preparation of fluoroalkenoates

Emmanuel Pfund1, Cyril Lebargy, Jacques Rouden

  • 1Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Basse-Normandie, CNRS, 6 boulevard du Maréchal Juin, 14050 Caen, France.

The Journal of Organic Chemistry
|September 21, 2007
PubMed
Summary

A modified Julia olefination reaction offers a stereoselective synthesis for fluoroalkenoate derivatives. Optimized conditions using DBU and MgBr2 provide efficient access to both (Z)- and (E)-alkenoates.

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