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Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
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Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by &#960;-&#960; Stacking Interactions
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Poly(ethylene oxide) based copolymers: solubilisation capacity and gelation.

David Attwood1, Zhengyuan Zhou, Colin Booth

  • 1University of Manchester, School of Pharmacy and Pharmaceutical Sciences, Manchester M13 9PL, UK. david.attwood@manchester.ac.uk

Expert Opinion on Drug Delivery
|September 21, 2007
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Summary

Amphiphilic block copolymers offer solutions for poorly soluble drugs. Newer designs enhance drug loading and enable in situ gelling for improved delivery systems.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Many drug candidates fail due to poor aqueous solubility and absorption.
  • Colloidal delivery systems, particularly nanosized particles, are developed to overcome these limitations.
  • Amphiphilic block copolymers form micelles capable of encapsulating hydrophobic drugs.

Purpose of the Study:

  • To review colloidal vectors based on amphiphilic block copolymers for drug delivery.
  • To discuss advancements in block copolymer design for enhanced drug loading and solubility.
  • To explore the potential of these systems as in situ gelling vehicles.

Main Methods:

  • Focus on poly(oxyethylene)-based block copolymers with various hydrophobic blocks (poly(oxyalkylene), polyester).
  • Analysis of micelle formation and drug encapsulation capabilities.
  • Review of recent developments in hydrophobic core design for improved drug compatibility.
  • Evaluation of thermally reversible gelation properties for in situ gelation applications.

Main Results:

  • Traditional Pluronic polyols show limited drug solubilization capacity.
  • Novel block copolymers with more hydrophobic cores demonstrate higher drug loading.
  • Recent designs achieve high drug loading combined with thermally reversible gelation.
  • These advanced copolymers show promise for subcutaneous injection and in situ gel formation.

Conclusions:

  • Amphiphilic block copolymers are effective colloidal carriers for poorly soluble drugs.
  • Tailored hydrophobic blocks significantly enhance drug loading capacity.
  • Thermally responsive block copolymers offer potential for advanced in situ drug delivery systems.