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Related Experiment Video

Updated: Jul 11, 2026

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

Is the septic response good or bad?

Willem Joost Wiersinga¹, Tom van der Poll

¹Academic Medical Center, Meibergdreef 9, Room G2-132, 1105 AZ Amsterdam, the Netherlands.

Current Infectious Disease Reports

|September 21, 2007

Summary

This summary is machine-generated.

The body needs a balance between inflammatory and anti-inflammatory responses to fight pathogens. Sepsis, often seen as excessive inflammation, may require a reevaluation of its role in survival.

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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

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Published on: December 9, 2022

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Last Updated: Jul 11, 2026

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Area of Science:

Immunology
Pathophysiology
Microbiology

Background:

Maintaining a balance between inflammatory and anti-inflammatory responses is crucial for pathogen defense.
Sepsis has traditionally been defined as a dysregulated inflammatory response to infection.

Purpose of the Study:

To review current trends and developments in sepsis research.
To explore the ongoing debate regarding the beneficial or detrimental nature of the sepsis response.

Main Methods:

Literature review of recent sepsis research.
Analysis of evolving concepts in the sepsis field.

Main Results:

Emerging evidence challenges the traditional view of sepsis as solely detrimental.
New insights suggest a more complex role for the host response in sepsis.

Conclusions:

The established sepsis paradigm is being re-examined.
Further research is needed to fully understand the dual nature of the inflammatory response in sepsis.