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Updated: Jul 11, 2026

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
Published on: July 29, 2022
Is the septic response good or bad?
Willem Joost Wiersinga1, Tom van der Poll
1Academic Medical Center, Meibergdreef 9, Room G2-132, 1105 AZ Amsterdam, the Netherlands.
Abstract:
A careful balance between the inflammatory and anti-inflammatory response is vital in order to survive the daily invasion of pathogens. Sepsis has always been regarded as the result of an exacerbated detrimental inflammatory response towards invading bacteria. However, recent insights have forced us to rethink this sepsis paradigm. This review discusses the latest trends and developments in the sepsis field and helps to set the stage for the current debate on whether the sepsis response is good or bad.
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