Related Experiment Video
Updated: Jul 11, 2026
07:12
Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis
Published on: February 10, 2026
Levemir Early Clinical Experience Case Series.
1Yale School of Medicine, New Haven, Connecticut, USA. abmayerson@aol.com
Endocrinology and Metabolism Clinics of North America
|October 16, 2007
Summary
Insulin detemir improved glycemic control in type 2 diabetes patients, reducing fasting blood glucose and A1C levels. The treatment was well-tolerated with minimal hypoglycemia and some weight loss.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Pharmacology
Background:
- Type 2 diabetes mellitus (T2DM) management requires effective glycemic control.
- Insulin therapy is a cornerstone in T2DM treatment, with basal insulins offering a simplified regimen.
- Insulin detemir represents a long-acting basal insulin analog.
Observation:
- A case series analyzed 43 patients with T2DM treated with insulin detemir.
- Data collected included glycemic control (FBG, A1C), tolerability (hypoglycemia, weight), dosing, and discontinuation.
- Patients were either insulin-naive or previously on insulin therapy.
Findings:
- Insulin detemir significantly improved glycemic control, with mean FBG decreasing by 63 mg/dL and mean A1C dropping from 8.6% to 7.0%.
- The treatment demonstrated good tolerability, with only four patients reporting mild hypoglycemic episodes and a mean weight loss of 5 lb.
- Approximately 91% of patients utilized a once-daily dosing regimen, with a low discontinuation rate.
Implications:
- Early clinical experience with insulin detemir in the US suggests favorable outcomes for T2DM patients.
- These findings align with established evidence from controlled trials and large observational studies.
- Insulin detemir appears to be an effective and well-tolerated option for basal insulin therapy in T2DM.
Related Concept Videos
01:11Clinical Trials: Overview
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
01:16Clinical Trials
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
01:28Preclinical Development: Overview
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
01:26Introduction and Methods of Leveling
Leveling is a surveying procedure used to determine elevation differences between distant points. Elevation refers to the vertical distance above or below a reference datum, typically mean sea level (MSL). In the United States, elevations are often referenced to the mean sea level station at Father Point Rimouski along the St. Lawrence Seaway. To make the datum accessible, permanent markers are established throughout the region. These markers, called benchmarks, have known elevations. If the...