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Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

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Related Experiment Video

Updated: Jul 11, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

Acute basophilic leukaemia: a case report.

H R Kokandakar¹, P R Tembhare, Alfatmi Mamoon

¹Department of Pathology, Govt. Medical College, Aurangabad.

Indian Journal of Pathology & Microbiology

|September 22, 2007

Summary

Acute basophilic leukaemia is a rare cancer. Diagnosis can be challenging, but morphological features and toluidine blue staining offer a useful method for identifying this uncommon leukaemia.

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Published on: March 5, 2018

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Last Updated: Jul 11, 2026

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Published on: November 21, 2018

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Area of Science:

Hematology
Oncology
Molecular Diagnostics

Background:

Acute basophilic leukaemia (ABL) is a rare subtype of acute leukaemia.
Consistent diagnostic criteria for ABL remain under discussion due to its rarity.
Accurate identification often requires advanced techniques like immunophenotyping, electron microscopy, and cytogenetics.

Observation:

This case highlights diagnostic challenges in resource-limited settings.
Morphological assessment and metachromasia demonstration using toluidine blue stain were key diagnostic tools.
The patient presented with acute basophilic leukaemia and an (11q23)-MLL gene rearrangement.

Findings:

Morphological features and toluidine blue staining can be effective for diagnosing ABL when advanced facilities are unavailable.
The presence of (11q23)-MLL gene rearrangement was identified in this case.
This case underscores the importance of accessible diagnostic methods for rare leukaemias.

Implications:

Simple staining techniques can aid in the early diagnosis of rare leukaemias like ABL.
Improved diagnostic accessibility is crucial for effective management of patients with rare cancers.
Further research into standardized diagnostic criteria for ABL is warranted.