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Related Experiment Videos

Olfactory function and nasal nitric oxide.

H S Elsherif1, B N Landis, M H Hamad

  • 1Department of Otolaryngology Head and Neck Surgery, Tanta University, Tanta, Egypt.

Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
|September 22, 2007
PubMed
Summary
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In chronic rhinosinusitis patients, nasal nitric oxide (nNO) levels correlate with olfactory function, suggesting inflammation impacts both. However, nNO does not appear to directly influence olfaction in these patients or healthy individuals.

Area of Science:

  • Otolaryngology
  • Rhinology
  • Neuroscience

Background:

  • Chronic rhinosinusitis (CRS) is associated with impaired olfactory function.
  • Nasal nitric oxide (nNO) plays a role in sinonasal physiology and may be altered in CRS.

Purpose of the Study:

  • To investigate the relationship between nasal nitric oxide (nNO) concentration and olfactory function in patients with CRS.
  • To compare nNO levels and olfactory thresholds between CRS patients and healthy controls.

Main Methods:

  • A prospective study involving 64 CRS patients and 20 healthy subjects.
  • Nasal nitric oxide (nNO) concentration measured by chemiluminescence.
  • Olfactory thresholds assessed using the Sniffin' Sticks phenyl ethanol test preoperatively and 3 months post-endoscopic sinus surgery for CRS patients.

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Main Results:

  • Healthy subjects exhibited significantly higher nNO concentrations and better olfactory thresholds than CRS patients, both pre- and post-surgery.
  • Olfactory thresholds and nNO concentrations remained stable after surgery in the CRS group.
  • A positive correlation was observed between nNO concentrations and olfactory thresholds in CRS patients (preoperatively and post-surgery), but not in healthy controls.

Conclusions:

  • Olfactory function and nNO concentration are correlated in CRS patients, suggesting a common underlying inflammatory process rather than direct influence.
  • Nasal nitric oxide produced by the paranasal sinuses does not appear to directly impact olfactory function.
  • Inflammatory processes in CRS may affect both nNO production and olfactory perception.