Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gap Junctions

Gap Junctions

The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...

Gap Junctions

Gap Junctions

Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...

Channel Rhodopsins

Channel Rhodopsins

Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...

Electrochemical Gradient and Channel Proteins: An Overview

Electrochemical Gradient and Channel Proteins: An Overview

An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...

Ion Channels

Ion Channels

The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow specific...

Voltage-gated Ion Channels

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Epigenetic Modification as a Regulatory Mechanism for Spatiotemporal Dynamics of ANO1 Expression in Salivary Glands.

International journal of molecular sciences·2019

Same author

Tissue Distribution of Kir7.1 Inwardly Rectifying K<sup>+</sup> Channel Probed in a Knock-in Mouse Expressing a Haemagglutinin-Tagged Protein.

Frontiers in physiology·2018

Same author

Reply to Orešković et al.

Physiological reviews·2016

Same author

Nanomedicine: a pharma perspective.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology·2014

Same author

Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors.

Cancer chemotherapy and pharmacology·2014

Same author

Effects of octane derivatives on activity of the volume-regulated anion channel in rat pancreatic β-cells.

Pharmacological reports : PR·2014

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus

Published on: December 16, 2022

Ion channel diversity, channel expression and function in the choroid plexuses.

Ian D Millar¹, Jason Ie Bruce, Peter D Brown

¹Faculty of Life Sciences, Core Technology Facility, University of Manchester, Manchester M13 9NT, UK. Peter.D.Brown@manchester.ac.uk.

Cerebrospinal Fluid Research

|September 22, 2007

Summary

Researchers identified various ion channels in the choroid plexus, including potassium and anion channels, crucial for cerebrospinal fluid (CSF) secretion. Further research is needed to determine their exact roles.

More Related Videos

Targeted Knockdown of Genes in the Choroid Plexus

Targeted Knockdown of Genes in the Choroid Plexus

Published on: June 16, 2023

Manual Segmentation of the Human Choroid Plexus Using Brain MRI

Manual Segmentation of the Human Choroid Plexus Using Brain MRI

Published on: December 15, 2023

Related Experiment Videos

Last Updated: Jul 11, 2026

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus

Published on: December 16, 2022

Targeted Knockdown of Genes in the Choroid Plexus

Targeted Knockdown of Genes in the Choroid Plexus

Published on: June 16, 2023

Manual Segmentation of the Human Choroid Plexus Using Brain MRI

Manual Segmentation of the Human Choroid Plexus Using Brain MRI

Published on: December 15, 2023

Area of Science:

Neuroscience
Cell Biology
Physiology

Background:

Ion channel research has advanced significantly due to patch clamp techniques and molecular studies.
Understanding ion channel function in the choroid plexus is key to understanding cerebrospinal fluid (CSF) secretion.

Purpose of the Study:

To investigate the expression and potential roles of ion channels in the choroid plexus.
To identify specific potassium and anion conductances involved in CSF secretion.

Main Methods:

Utilized patch clamp electrophysiology to study ion channel activity.
Reviewed molecular evidence for channel expression in the choroid plexus.

Main Results:

Identified two K+ conductances (Kv1 and Kir 7.1) at the apical membrane.
Characterized two anion conductances with HCO3- permeability, one regulated by cyclic AMP and another by cell volume.
Detected non-selective cation channels, including TRPV4, TRPM3, and P2X receptors.

Conclusions:

Significant progress has been made in identifying choroid plexus ion channels.
The precise roles of these identified channels in CSF secretion require further investigation.