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06:09
Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
[Acute pyelonephritis. Prospective analysis of 91 cases]
L Force1, L Murgui, P Barrufet
1Servicio de Medicina Interna, Hospital L'Aliança, Mataronina, Barcelona.
Revista Clinica Espanola
|March 1, 1991
Summary
This study on acute pyelonephritis found E. coli is the most common cause. While initial treatment with gentamicin is effective, 22% of patients experienced recurrence, highlighting the need for further management strategies.
Area of Science:
- Nephrology
- Infectious Diseases
- Urology
Context:
- Acute pyelonephritis is a common kidney infection.
- Understanding its clinical manifestations and bacteriology is crucial for effective management.
- This study prospectively analyzes 99 patients with acute pyelonephritis.
Purpose:
- To analyze the clinical features, bacteriology, and treatment outcomes of acute pyelonephritis.
- To identify risk factors for complicated cases and recurrence.
- To evaluate the efficacy of gentamicin treatment and 14-day duration.
Summary:
- Fever and flank pain were the most common symptoms (97%).
- Bacteremia was present in 99% of cases, predominantly caused by E. coli (91%).
- Initial gentamicin treatment for 14 days showed a 2% failure rate but a 22% recurrence rate, with 15% developing complicated pyelonephritis.
Impact:
- Provides insights into the clinical presentation and microbiological profile of acute pyelonephritis.
- Highlights the high recurrence rate, suggesting potential need for optimized treatment protocols.
- Identifies a significant proportion of patients requiring urologic intervention for complicated cases.
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