Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lumbar degenerative disk disease.

Michael T Modic1, Jeffrey S Ross

  • 1Division of Radiology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA. modicm1@ccf.org

Radiology
|September 22, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Sequencing to Treatment: Operational Challenges in Translating Precision Oncology Into Clinical Practice.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting·2026
Same author

Neoadjuvant Sacituzumab Govitecan in Patients With Muscle-Invasive Bladder Cancer: Primary Results of the SURE-01 Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Ultra-high tumor mutation burden breast cancer: genomic profiling and real-world immunotherapy results.

NPJ breast cancer·2026
Same author

Homozygous Loss of Recombination Repair Genes and Poly ADP-Ribose Polymerase Inhibitor Benefit for Patients With Ovarian Cancer.

JCO precision oncology·2026
Same author

Genomics of <i>MTAP</i> Loss in >500,000 Solid Tumor Specimens Profiled Using Comprehensive Genomic Profiling Platforms.

JCO precision oncology·2026
Same author

Diabetic striatopathy associated with nonketotic hyperglycemia.

JCEM case reports·2026
Same journal

Erratum for: Prediction of Lobar Emphysema Progression with a CT-Based Foundational Model.

Radiology·2026
Same journal

Erratum for: Associations of MRI-derived Paraspinal IMAT and LMM with Cardiometabolic Risk Factors: Results from a German Cohort.

Radiology·2026
Same journal

Erratum for: Blue Rubber Bleb Nevus Syndrome.

Radiology·2026
Same journal

Redefining the Clinical Role of MRI in Endometrial Cancer Staging.

Radiology·2026
Same journal

To Ablate or Not to Ablate: The Colorectal Liver Metastasis Question.

Radiology·2026
Same journal

The Limits of Radiologic Categorization in Pulmonary Nonsolid Nodules.

Radiology·2026
See all related articles

Disk degeneration causes significant functional incapacity and chronic disability. Understanding its causes, pain mechanisms, and imaging

Area of Science:

  • Orthopedics
  • Radiology
  • Pain Medicine

Background:

  • Disk degeneration is a leading cause of functional incapacity and chronic disability.
  • It involves structural disruption and cell-mediated compositional changes.
  • Multiple factors contribute, including mechanical, traumatic, nutritional, and genetic influences.

Purpose of the Study:

  • To review the complexities of disk degeneration.
  • To explore the etiology of pain associated with degenerative disk disease.
  • To highlight the role of imaging and the need for accurate natural history data.

Main Methods:

  • Literature review of disk degeneration.
  • Analysis of factors contributing to degeneration and pain.
  • Discussion of the role of imaging in diagnosis and treatment planning.

Related Experiment Videos

Main Results:

  • Degenerative changes are highly prevalent, even in asymptomatic individuals.
  • Pain in degenerative disk disease is multifactorial, involving mechanical and inflammatory components.
  • Accurate natural history data is crucial for understanding disease progression and patient stratification.

Conclusions:

  • Effective management of degenerative disk disease requires understanding the interplay between etiologic factors, imaging findings, and pain mechanisms.
  • Improved patient cohort stratification is needed for better research and clinical decision-making.
  • Further research into the natural history and pain mechanisms of disk degeneration is warranted.