Related Experiment Videos
Efficacy of various pretreatment and therapy regimens against soman lethality in mice
Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove
|January 1, 1991
Abstract:
The efficacy of a number of drug pretreatment combinations in protecting mice against lethal effects of soman was determined. Pyridostigmine peroral pretreatment followed by intramuscular postpoisoning therapy with atropine, obidoxime and/or trimedoxime, and diazepam protected mice against the lethal action of soman. Combination of pyridostigmine with trihexyphenidyl, benactyzine and bis-(4-hydroxyiminomethyl) pyridinium-methane dichloride improved prophylactic action even further.