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Epilepsy associated with low-grade brain glial neoplasms
J Nĕmecková1, S Nĕmecek, J Náhlovský
1Department of Neurosurgery, Medical Faculty Charles University, Hradec Králové.
Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove
|January 1, 1995
Summary
Surgery for low-grade supratentorial gliomas can effectively control seizures in most patients. Tumor resection, often with adjuvant therapy, led to seizure freedom in two-thirds of cases, suggesting the tumor
Area of Science:
- Neurosurgery
- Neurology
- Oncology
Background:
- Low-grade supratentorial gliomas frequently present with seizures.
- Seizures associated with these tumors are often refractory to medical management.
Purpose of the Study:
- To evaluate the efficacy of surgical resection in controlling seizures in patients with low-grade supratentorial gliomas.
- To investigate the role of tumor infiltration in epileptogenesis.
Main Methods:
- Retrospective analysis of 52 patients who underwent surgery for low-grade supratentorial gliomas between 1991-1993.
- Tumor resection without intraoperative electrocorticography.
- Adjuvant radiotherapy and chemotherapy in select cases.
Main Results:
- 37 patients presented with seizures, often drug-refractory.
- Postoperative seizure freedom was achieved in approximately two-thirds of the 33 surviving patients (mean follow-up 28 months).
- Histological analysis suggested peripheral tumor infiltration may contribute to epileptogenesis.
Conclusions:
- Surgical resection is an effective treatment for seizure control in patients with low-grade supratentorial gliomas.
- The peripheral zone of cortical tumor infiltration may play a role in seizure development.
- Further research into the mechanisms of epileptogenesis in gliomas is warranted.