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Updated: Jul 11, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
Published on: November 22, 2021
On-line grasp control is mediated by the contralateral hemisphere
Nichola J Rice1, Eugene Tunik, Emily S Cross
1HB 6162 Moore Hall, Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire 03755, USA.
The anterior intraparietal sulcus (aIPS) plays a key role in grasping. This study shows that the left aIPS controls grasping with the right hand, and the right aIPS controls grasping with the left hand.
Area of Science:
- Neuroscience
- Motor Control
- Cognitive Neuroscience
Background:
- The anterior intraparietal sulcus (aIPS) is implicated in prehensile movements based on electrophysiological, imaging, and neuropsychological studies.
- Recent advancements in transcranial magnetic stimulation (TMS) allow for causal attribution of function to specific brain regions like the aIPS in grasping.
- Previous research indicates aIPS involvement in both executing grasps and correcting movements during target perturbations.
Purpose of the Study:
- To investigate the differential contribution of the left and right hemisphere aIPS to grasping movements.
- To determine the hemispheric lateralization of grasping control using TMS.
Main Methods:
- Utilized transcranial magnetic stimulation (TMS) to transiently disrupt activity in the left and right aIPS at movement onset.
- Assessed the impact of aIPS disruption on grasping movements performed with the left and right hands.
Main Results:
- Transient disruption of the left aIPS impaired grasping with the right hand but not the left hand.
- Transient disruption of the right aIPS impaired grasping with the left hand but not the right hand.
Conclusions:
- Grasping is a lateralized motor process, exclusively relying on the contralateral hemisphere.
- These findings have implications for understanding models of hemispheric dominance in motor control.
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